Heat Induces Histone γH2AX Formation under Hypoxia
نویسندگان
چکیده
منابع مشابه
TSSK6 is required for γH2AX formation and the histone-to-protamine transition during spermiogenesis.
Spermiogenesis includes transcriptional silencing, chromatin condensation and extensive morphological changes as spermatids transform into sperm. Chromatin condensation involves histone hyperacetylation, transitory DNA breaks, histone H2AX (also known as H2AFX) phosphorylation at Ser139 (γH2AX), and replacement of histones by protamines. Previously, we have reported that the spermatid protein k...
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Hypoxia increases both active and repressive histone methylation levels via decreased activity of histone demethylases. However, how such increases coordinately regulate induction or repression of hypoxia-responsive genes is largely unknown. Here, we profiled active and repressive histone tri-methylations (H3K4me3, H3K9me3, and H3K27me3) and analyzed gene expression profiles in human adipocyte-...
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ژورنال
عنوان ژورنال: Thermal Medicine
سال: 2018
ISSN: 1882-2576,1882-3750
DOI: 10.3191/thermalmed.34.45